Through the creation of a series of 3D printed artworks a diagrammatic method is used to support a both intuitive and controlled framework for creation of sculptural artwork work with artistic sensibility. This presentation investigates the use of such a method to evaluate a given artistic situation, with the intent to approach the essential needs in artistic creation. The specific diagrammatic methodology is inspired by and further elaborated from C. S. Peirce’s semiotic system consisting of interrelated signs, wherein the diagram holds a very special position in the semiotic reasoning process. Artistic creation seen through the specific diagrammatic approach indicates that it can be possible to establish the process of creation according to this diagrammatic system, with a flexibility that allows for an artistic sensitivity and unpredictability as a main driver. Using the semiotic diagrammatic approach can be useful for understanding the creation of artworks on a crossbreed platform involving both artistic inspiration, traditional skills, and new technologies such as 3D printing. In the creative process taking on digital systems, it is significant to address the role of user interfaces, which act as a translator between the code and the artist. Controlling software in a desired direction, requires an increased awareness. With a semiotic diagrammatic understanding, we can pose informed questions about artistic processes. We can understand the creative artistic work as a series of interrelated signs, and discern the types of requirements for input in the various steps, and how these sign-relations manifest themselves and are perceived differently in different contexts. This presentation will exemplify and introduce to the diagrammatic reasoning as an opportunity to raise the awareness about the ongoing processes in the creative work of art in a digital context. All the used examples of artwork are created by the author.